With more than 30 known types of protein misfolding diseases, the majority have no approved therapies. This is not surprising given the following challenges and barriers to drug discovery:
- How does one design a drug that targets the often-scarce disease-causing forms of the protein, while avoiding the abundant, healthy forms which often perform important and critical functions in the body?
- How does one unravel the often complex disease mechanisms that underlie protein misfolding diseases and use this to design an effective therapeutic strategy?
- How can one be sure that the therapeutic intervention functions as intended and ensures that it encapsulates precision-based medicine?
Paradox’s unique approach includes capitalizing on our experience in the field of protein misfolding research and the use of a groundbreaking lead identification and validation platform that gives us a competitive edge to overcome these challenges.